Faculty : Faculty

Yanbin Zhang, PhD

Associate Professor of Biochemistry and Molecular Biology
Primary Appointment of Biochemistry and Molecular Biology
(305) 243-9237
yzhang4@med.miami.edu
Gautier Building Room #311
Research Area: Mechanisms of Human DNA Repair, Interstrand Cross-Link Repair and Mismatch Repair.
Lab Info: Dr. Yanbin Zhang Lab
Publications: PubMed

Research Summary:

Interstrand crosslinks (ICLs) are among the most toxic DNA lesions, since they covalently tether both duplex DNA strands and prevent essential DNA metabolism such as replication and transcription. Deficient ICL repair underlies the cancer-prone hereditary syndrome Fanconi anemia. We are interested in deciphering the molecular mechanism of ICL repair, delineating role of Fanconi anemia proteins in DNA repair, and studying the relationship between Fanconi anemia proteins and human cancers. Our research relies on a biochemically defined reconstitution system and cell-based analyses.

Education:

  • 1998 PhD Peking University