Faculty : Faculty

Stephen Lee, PhD

Professor of Biochemistry and Molecular Biology
Director, The Executive Ph.D. Program
Leader of the Tumor Biology Program, Sylvester Comprehensive Cancer Center
Chair, The Scientific Advisory Board, Sylvester Comprehensive Cancer Center
Primary Appointment of Biochemistry and Molecular Biology
(305) 243-5177
Gautier Building Room #216
Research Area: RNA Structure & Metabolism.
Lab Website: StephenLeeLab.com
Publications: PubMed

Research Interests:

The laboratory studies mechanisms involved in the cellular adaptation to the adverse environmental conditions commonly found within the tumor microenvironment (hypoxia and extracellular acidosis). These extracellular stimuli alter fundamental cellular pathways by
  1. Activating an alternate translation apparatus that synthesizes proteins only in the absence of oxygen and
  2. Inducing a new class of long noncoding RNAs that regulate protein function.
    Ongoing projects blend basic and translational scientific research from the identification of novel stress-induced long noncoding RNA to discovery of drug as small molecular inhibitors for these essential tumor biology pathways.

Recent Selected Publications from my Lab:

Ho et al. (2016) Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus. Cell rep. PMID: 26854219. Read more…

Lachance et al. (2014) DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia. Proc. Natl. Acad. Sci. (USA) PMID: 24817692. Read more…

Uniacke et al. (2012) An oxygen-regulated switch in the protein synthesis machinery. Nature. PMID: 22678294. Read more…

Audas et al. (2012) Immobilization of proteins in the nucleolus by ribosomal intergenic spacer noncoding RNA. Mol. Cell. PMID: 22284675. Read more…

Additional publications at: